The Golden Role of Natural Products in Obesity

Gehan F Abdel Raoof1,*, Aya M Z Abd El Kareem2

1Pharmacognosy Department, Pharmaceutical and Drug Research Industries Division, National Research Centre, Dokki, Giza 12622, Egypt.
2College of Biotechnology, Misr University for Science and Technology (MUST), Egypt.

Abstract: Objective: Obesity is considered a serious syndrome that can have a negative impact on the whole systems in the body which leads to many health problems, such as osteoarthritis, heart disease, diabetes, and certain cancers. Up to date reports revealed that there are more than 700 million obese people throughout the world. However, surgery and synthetic drugs may be a choice for the treatment of obesity; they showed unsatisfying results with serious adverse effects. So the best option for the management of obesity is a lifestyle modification together with using natural alternatives that showed the minimal side effects. Natural Products are rich of bioactive compounds that have been used as traditional medicine. Some active natural products were tested by clinical trials and they showed a powerful impact in the treatment of obesity. Aim: This review is focused on the recent advances in the natural products as anti-obesity potential. A major focus is to highlight the mechanisms of action of natural products as anti-obesity agents, as well as the structure-activity studies, preclinical and clinical trials were also discussed. Results: The current review revealed that natural products include diversity of phytoconstituents that play an important role in the treatment of obesity.

Keywords:Anti-obesity, bioactive compounds, natural products, Obesity.


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